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SPECTROPHOTOMETRIC DETERMINATION OF NIACIN, THIAMINE, GLIBENCLAMIDE, ERYTHROMYCIN AND PARA AMINO BENZO IC ACID USING 2, 3 – DICHLORO – 5, 6 – DICYANO – 1, 4 – BENZOQUINONE

ABSTRACT A simple and sensitive spectrophotometric method is described for the assay of the drugs; niacin, glibenclamide, erythromycin, thiamine and 4-aminobenzoic acid. The method is based on charge transfer complexation (CT) reaction of niacin, glibenclamide, erythromycin, thiamine and 4-aminobenzoic acid as n-electron donors with 2,3-dichloro-5,6-dicyno-1,4-benzoquinone(DDQ) as л-electron acceptor in methanol. Intensely coloured charge transfer complexes […]

SPECTROPHOTOMETRIC DETERMINATION OF PARACETAMOL USING ZIRCONIUM (IV) OXIDE AND AMMONIUM TRIOXOVANADATE (V)

TABLE OF CONTENTS Title page ————————————————————————– i Certification———————————————————————– ii Dedication ———————————————————————— iii Acknowledgment—————————————————————– iv Table of Contents —————————————————————- v List of Tables———————————————————————- vi List of Figures——————————————————————— vii Abstract —————————————————————————- viii   CHAPTER ONE 1.0 Introduction —————————————————————– 1 1.1 Ultraviolet – visible spectrophotometry (UV – visible spectrophotometry).——————————————————– 1 1.2 Paracetamol —————————————————————— 4 1.3 The structure of […]

SYNTHESIS AND CHARACTERIZATION OF ALKYLATED ISOCYANATE DERIVATIVES OF [Pt2(µ-S)2(PPh3)4]

CHAPTER ONE  Introduction 1.1      Background of Study              Investigation of the chemistry of platinum and sulphur has attracted considerable attention in recent years due to the broad applications of the two elements and their compounds, in biological systems1, applied catalysis2,3 and to the chemistry of novel molecular systems4. Other main areas of application are in the design […]

SYNTHESIS AND CHARACTERIZATION OF ZEOLITE AND ITS APPLICATION IN ADSORPTION OF NICKEL FROM AQUEOUS SOLUTION

CHAPTER ONE Introduction Zeolites are porous crystalline alumino-silicates of regular skeleton structures formed by alternating silicon-oxygen and aluminum-oxygen tetrahedrons. Although only natural zeolites were initially used, synthetic zeolites, due to their well-tailored and highly-reproducible structures, have been used extensively as ion exchangers, adsorbents, separation materials and catalyst1.The negative charges in aluminum-oxygen tetrahedron, which are not rigidly fixed […]

SYNTHESIS AND CHARACTERIZATION OF ZINC OXIDE NANOWIRE

CHAPTER ONE INTRODUCTION 1.1 Background of the Research Nanoscience evolution and the advent of nanowire fabrication marked a new epoch in optoelectronics 1. Characteristic investigation for achieving efficient light absorption, charge separation transport and collection had culminated in the synthesis of both organic and inorganic semiconductor nanowires 2-3. The d-block transition elements of the periodic table are all […]

SYNTHESIS, CHARACTERIZATION AND SOLVENT EXTRACTION STUDIES OF 3,5-BIS[(2-HYDROXY-BENZYLIDENE)-AMINO]-BENZOIC ACID AND ITS Co(II) AND Ni(II) COMPLEXES

ABSTRACT In this study, a series of N-pyridin-3-yl substituted [phenylsulphonamido] acetamide has been synthesized. The reaction of phenylsulphonyl chloride with various amino acids in basic medium yielded phenylsulphonamido alkanoic acid which, on chlorination with thionyl chloride, gave acid chloride derivatives of phenylsulphonamido alkanoic acid in situ. The acid chloride derivatives on condensation with 3-aminopyridine gave corresponding acetamide in […]

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL STUDIES OF 4-ACYLPYRAZOLONE COMPLEXES OF SOME d-BLOCK ELEMENTS

CHAPTER ONE 1.0       Introduction Investigation on 4-acyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (4-acylpyrazol-5-one) and its transition metal complexes has attracted significant attention because of their applications as extractants1, antipyretic2, analgesic3, antitubercular4, antimycobacterial5, antibacterial6, antifungal7, and antineoplastic8 drugs. 4-acylpyrazol-5-one, is an enolizable ligand with strong ligating ability. These ligands are synthesized by direct acylation at C – 4 of 3-methyl-1-phenyl-1H-pyrazol (4H)-5-one (PMP) […]

SYNTHESIS OF NHETEROARYL SUBSTITUTED

CHAPTER ONE 1.1       INTRODUCTION The basic sulphonamide group –SO2NH- occurs in various biological active compounds including antimicrobial drugs, antithyroid agents, antitumor antibiotics and inhibitors of carbonic anhydrase1,2.  Sulphonamides are widely used to treat microbial infection by inhibiting the growth of gram-negative and gram-positive bacteria, some protozoa and fungi3. Clinically, sulphonamides are used to treat several urinary […]

TANDEM AMINATION CATALYSIS IN THE SYNTHESIS OF DIAZAPHENOXAZINE COMPOUNDS OF PHARMACEUTICAL INTEREST

ABSTRACT The synthesis and characterization of five new linear diazaphenoxazine compounds is reported. The key intermediate, 3-chloro-1-9-diazaphenoxazine, was prepared via a base catalyzed reaction of 2-amino-3-hydroxypyridine with 2,3,5-trichloropyridine in aqueous 1, 4-dioxane. Five 3-amino derivatives of the key intermediate were prepared via Buchwald – Hartwigamination coupling reaction between 3-chloro-1,9-diazaphenoxazine and various heterocyclic amines, under the […]

THE DESIGN AND CONSTRUCTION OF A SPIN DRYER

ABSTRACT This work is aimed at designing and fabricating a spin dryer which can be used in drying spent grains after brewing. This will no doubt save considerable human labours and time wastage involved in conventional method of drying the spent grains by spreading on the ground. It also saves as a means of employments […]

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