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EVALUATION OF PHARMACOGNOSTICPARAMETERS AND HEPATOTOXIC EFFECTS OF EXTRACTSOF CASSYTHA FILIFORMIS LINN ON PARACETAMOL-INDUCED LIVER DISORDERS IN WISTER RATS

ABSTRACT Cassytha filiformis, a leafless and perennial vine with small scales as a replacement of the leavesis currently being used in the treatment of various disease conditions including jaundice without standardization.Microscopical evaluation, chromatographic analysis (TLC, HPLC, LC-MS/MS), spectroscopic analyses (NMR, FTIR, MS) and hepathoprotective studies were carried out with the view to scientifically verify the […]

PHARMACOECONOMIC ANALYSIS OF HIV/AIDS MANAGEMENT

ABSTRACT The HIV/AIDS pandemic has resulted in mortality surge and life expectancy drop throughout the world. Developing countries are mostly affected due to their limited health care system and resources to handle the increasing costs of management of HIV/AIDS and associated opportunistic infections. The objective of this study is to estimate direct and indirect costs […]

ANTIMICROBIAL ACTIVITY OF METHANOL EXTRACT AND FRACTIONS OF MORINGA OLEIFERA LAM. ROOT BARK ON CLINICAL ISOLATES OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS

ABSTRACT Development of antimicrobial resistance by bacteria is now a world wide health issue, as infection is one of the leading causes of death in the world today. This fact is also as a result of the emergence of multiple antibiotic resistant bacteria known as methicillin resistant Staphylococcus aureus (MRSA) with potential of cross resistance […]

PHYTOCHEMICAL STUDIES AND EVALUATION OF THE ANTITRYPANOSOMAL ACTIVITY OF VITEX SIMPLICIFOLIA OLIV. (VERBENACEAE) LEAF

ABSTRACT Background Trypanosomiasis, a disease of major importance in human and animals has continued to threaten human health and economic development. Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense as the etiological agents of trypanosomiasis affect millions of people in sub-saharan Africa and are responsible for the death of about half a million patients per year. […]

ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECTS OF PHASEOLUS VULGARIS LINN IN WISTAR RATS

ABSTRACT In this study, the antihyperlipidemic and antioxidants activities of the extract and fractions of Phaseolus vulgaris L. were evaluated. The crude extract (PVE) of dried pulverized plant material was obtained by maceration in methylene chloride/methanol (1:1) while the solvent fractions were obtained by successive solvent-solvent partition in separating funnel between the crude extract suspended […]

WOUND HEALING AND ANTI-INFLAMMATORY ACTIVITIES OF CEIBA PENTENDRA (L.) GAERTN IN WISTAR RATS

ABSTRACT Wound healing is a natural process that enables tissue repair after an injury while inflammation is a pathophysiological response of living tissue to injuries. To shorten the duration and minimize associated complications of wounds, wounds are treated with medications. Currently there is a growing interest in the use of traditional wound dressing agents such […]

PHARMACOLOGICAL ASSESSMENT OF Lupinus arboreus Sims (FABACEAE) METHANOL EXTRACT AND THREE ACTIVE CONSTITUENTS FOR ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS

ABSTRACT The methanol extract and chemical constituents of Lupinus arboreus leaf were investigated for antinociceptive and anti-inflammatory activities. The study was by experimental design. the extract was partitioned to yield hexane, ethylacetate, and methanol fractions. Phytochemical tests were done on the extract and fractions. Acute toxicity test (LD50) was carried out on crude methanol leaf […]

ECOFRIENDLY SYNTHESIS OF METFORMIN LOADED SILVER NANOPARTICLES USING NATURAL POLYMERS AND SYNTHESISED STARCH AS STABILIZING AGENTS

ABSTRACT Metformin loaded silver nanoparticles were synthesized using ecofriendly method with extract of Azadiractha indica as reducing agent and two natural polymers; guar gum and xanthan gum, Sodium alginate, and a semi- synthetic polymer (AMS) as stabilizing agents. Twelve batches of nanoparticles were synthesized. Nanocomposites synthesized from AMS were designated as AMS 1% NANOmet, AMS3% […]

ANTIHYPERLIPIDEMIC AND ANTIOXIDANT EFFECTS OF PHASEOLUS VULGARIS

ABSTRACT In this study, the antihyperlipidemic and antioxidants activities of the extract and fractions of Phaseolus vulgaris L. were evaluated. The crude extract (PVE) of dried pulverized plant material was obtained by maceration in methylene chloride/methanol (1:1) while the solvent fractions were obtained by successive solvent-solvent partition in separating funnel between the crude extract suspended […]

THE CAUSES AND EFFECTS OF CHOLERA AMONG CHILDREN

ABSTRACT This research work was designed to examine and analyze the causes and effects of cholera during raining season in Benin City. Seven (7) research questions were formulated and questionnaires were administered to one hundred and fifty (150) respondents in order to gather data for the research. Results showed that poor environment sanitation leads to […]

INVESTIGATION OF THE SOCIAL AND ECONOMIC IMPACT AND CONSEQUENCES OF CHRONIC DISEASES ON LOW INCOME EARNING FAMILY

Chapter one Introduction  1.1  Background of the Study It is well documented that in public health terms chronic diseases have come to “matter” in developing countries, where they impose a sizeable and growing disease burden (WHO 2001). The Global Burden of Disease (GBD) project estimates that as of 2002, chronic or non-communicable conditions accounted for […]

PROFILE OF ANTIBIOTIC USE AT THE HEALTH CENTRE

Abstract The indiscriminate use of antibiotics has become a global problem with implications for effective therapy of infections and dose resistance. The objective of this study is to determine the profile of antibiotic use at the health centre of Delta State University, Abraka. This study was a retrospective study of 592 patient prescriptions from January […]

ESTIMATION OF THE EFFECT OF CISAMPELOUS OWANRENSIS BENZENE FRACTION ON GLUCOSE ABSORPTION ACROSS THE INTESTINAL EPITHELIUM OF WISTER RATS ON ALOXAN INDUCED DIABETES

ABSTRACT Diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. It is generally characterized by hyperglycaemia and hyperlipidaemia culminating in severe morbidities. This study aimed to assess the effects of Cissampelos owanrensis on glucose absorption in alloxan-induced diabetic male Wistar rats. Twenty (20) adult. Wistar rats were […]

THE EFFECT OF Cisampelous Owarensis BENZENE FRACTION ON GLUCOSE ABSORPTION ACROSS THE INTESTINAL EPITHELIUM OF WISTER RATS ON ALOXAN INDUCED DIABETES

ABSTRACT Diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. It is generally characterized by hyperglycaemia and hyperlipidaemia culminating in severe morbidities. This study aimed to assess the effects of Cissampelos owanrensis on glucose absorption in alloxan-induced diabetic male Wistar rats. Twenty (20) adult Wistar rats were divided into […]

INVESTIGATING THE PRESENCE OF STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI IN DAIRY PRODUCTS

CHAPTER ONE INTRODUCTION 1.1 BACKGROUND OF THE STUDY Dairy products are various products derived from cow’s milk or that of other female mammals such as goat, sheep, yaks, horses, camel. Dairy products include yoghurt, nono (fermented cow’s milk, madara (unfermented cow’s milk, cheese, whey, condensed and evaporated milk.) (cultureforhealth, 2015). Yoghurt, nono, Madara has become […]

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF RISPERIDONE IN PURE AND TABLET DOSAGE FORMS

ABSTRACT Two simple, sensitive, accurate and extraction-free spectrophotometric methods were developed and described for the determination of risperidone in pure and in tablet dosage forms. The methods are based on the formation of ion-pair complex between risperidone and the dyes bromocresol green in method A and thymol blue in method B at room temperature to […]

BACTERIA RESPONSIBLE FOR UPPER URINARY TRACT INFECTION

BACTERIA RESPONSIBLE FOR UPPER URINARY TRACT INFECTION IN 5 CHILDREN ATTENDING GOVERNMENT SECONDARY SCHOOL MAKARFI  CHAPTER ONE  INTRODUCTION 1.1. Introduction In biology/ecology, parasitism is a non-mutual symbiotic relationship between species, where one species, the parasite, benefits at the expense of the other, the host. Traditionally parasite (in biological usage) referred primarily to organisms visible to […]

AUTOMATION IN INVENTORY MANAGEMENT IN THE PHARMACEUTICAL UNIT OF THE HOSPITAL

CHAPTER ONE INTRODUCTION 1.0 Introduction A pharmaceutical inventory management system is a computerized system that facilitates the inventory management of pharmaceutical products. An automated inventory management system can be categorized as an aspect of computer field of management information system (MIS) and it cannot exist without a proper database management which remains one of the […]

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